Doctorate in Biotechnology and Bioentrepreneurship

The Doctoral Program in Biotechnology and Bioentrepreneurship is based on the fact that the technological revolution, and the demands of international competitiveness for productive companies, impose the need for a strong rapprochement between academia and the productive sector.

This program is taught in alliance between Universidad San Sebastián and Fundación Ciencia y Vida.





PhD/Doctor in Biotechnology and Bioentrepreneurship

Application Period

Coming soon


8 semesters

Start Date

March 2024



Dr. Pablo Valenzuela V.
Program Director
Dra. Marcela Bravo Z.
Academic Secretary


The Doctoral Program in Biotechnology and Bioentrepreneurship is based on the fact that the technological revolution and the demands of international competitiveness for productive enterprises, impose the need for a strong rapprochement between academia and the productive sector.

The preparation of professionals with advanced training in the area of biotechnology is a challenge that requires great changes with respect to the classical training in science and in the way of approaching the Academy-Industry relations.

Today’s researchers, in addition to mastering the fundamental topics of biological sciences, must be versatile and multidisciplinary and apply the stages and requirements for entrepreneurship, business creation and requirements for transferring technologies and products from the laboratory to the market.

The program seeks to train students in the fundamental stages and characteristics of a science-based biotechnology venture. To this end, it includes models of entrepreneurship and financing mechanisms for start-ups that consider angel financiers, venture capital groups, capital increases, series A, B, etc.

It also considers concepts of intellectual property and technology transfer, and will study the requirements to obtain a patent and the processes to file patent applications in the United States, Europe and Chile.

The contents of patents will be studied and different examples will be analyzed. Patent searches and applications will be performed in various databases in Chile and the world, and the different types of licenses used in business agreements will be discussed.

Finally, students will work on the formulation of an application for a particular biotechnological invention including claims and its filing strategy to worldwide patent offices. The program includes training in the registration process of products in the health area in the United States, Europe and Chile.

Among the attributes of the program, the following stand out:

  • Privileged environment for its development in connection with biotechnology companies.
  • State-of-the-art and high standard infrastructure.
  • Research unit in companies.

Program Objectives

  • To train independent researchers capable of formulating and developing innovation projects and biotechnology transfers, generating original solutions to the problems of the productive sector, with leadership in the direction of multidisciplinary research teams, ethically complying with the protocols and norms that govern their performance.
  • To train students in specialized and updated knowledge about the advances in biotechnology worldwide and its applications in different areas of the productive sector in Chile and abroad, preparing them to recognize and apply the stages and requirements necessary to transform ideas and technologies into products.
  • To prepare students in the skills and attitudes to be able to discern the problems of the national productive sector that are accessible to biotechnological solutions.
  • To train students in broad knowledge of concepts and requirements associated with entrepreneurship and the creation of bioscience companies, especially in the international arena and in the concepts of intellectual property, patents and patentability requirements.
  • To contribute to the production of frontier knowledge and its communication in publications and scientific dissemination.

Lines of Research

Lines of Research
  1. Development of new bio-based technologies and their uses in Biomedicine.
  2. Microbiome, Viroma, Bacterial Ecophysiology, and associated Biotechnologies.
Research topics

The lines of research are subdivided into several research topics:

  • Immunotherapy and Cancer
  • Autoimmunity, Neurodegeneration
  • Stress Response and Neurodegeneration
  • Immunotherapy and Virus Mediated Cardiopulmonary Syndrome
  • Nanomaterials and Biomolecules in Medicine
  • Muscular Dystrophy, Translational Medicine and Mechanotransduction
  • Biophysics of Macromolecules
  • Development of Antiviral Strategies
  • Epigenetics and Cell Regulation
  • Ecophysiology of Extremophilic Microorganisms

Profile of Graduates

The graduate of the PhD in Biotechnology and Bioentrepreneurship of Universidad San Sebastian, is a researcher who:

  • Generates new knowledge through experimental research with a solid background in basic biological technologies and their implications in Biotechnology. In addition, demonstrates advanced knowledge to analyze and apply the mechanisms of technology transfer that allow the transition of new knowledge towards the formation of high-tech companies in the biological area.
  • Develops interdisciplinary research projects leading research teams, with the highest levels of excellence, rigor and ethics, applying and integrating methodologies relevant to biotechnology and bioentrepreneurship.
  • Performs innovative teaching in higher education according to the student-centered teaching-learning process.
  • Communicates knowledge and research results through publications in specialized journals.
  • Links scientific knowledge with the concerns and needs of society and transmits it in an understandable way to the general public and other specific groups.


Academic Faculty

Our Academic Faculty members have a track record of excellence in research at national and international level, active participation in basic and applied research projects and extensive experience in the training of advanced human capital.

María Inés Barría Cárcamo
María Inés Barría Cárcamo Doctora en Microbiología, Universidad de Chile, Chile.
María Inés Barría Cárcamo
Enrique Brandan Siques
Enrique Brandan Siques Doctor en Ciencias Biológicas, P. Universidad Católica de Chile.
Enrique Brandan Siques
Alfonso González De la Rosa
Alfonso González De la Rosa Doctor en Ciencias con mención en Biología Celular, P. Universidad Católica de Chile, Chile.
Alfonso González De la Rosa
David Holmes
David Holmes Doctor en Bioquímica, California Institute of Technology, USA.
David Holmes
Varaprasad Kokkarachedu
Varaprasad Kokkarachedu Doctorado en Ciencias y Tecnología de Polímeros
Varaprasad Kokkarachedu
Álvaro Lladser Caldera
Álvaro Lladser Caldera Doctor en Ciencias Biomédicas, Universidad de Chile, Chile.
Álvaro Lladser Caldera
Alejandra Loyola Pedevila
Alejandra Loyola Pedevila Doctor en Bioquímica, Universidad Rutgers, USA.
Alejandra Loyola Pedevila
Soledad Matus Montero
Soledad Matus Montero Doctora en Ciencias Biológicas, P. Universidad Católica de Chile.
Soledad Matus Montero
Iván Ñancucheo Cuevas
Iván Ñancucheo Cuevas Doctor en Microbiología Ambiental, Bangor University, Reino Unido.
Iván Ñancucheo Cuevas
Rodrigo Pacheco Rivera
Rodrigo Pacheco Rivera Doctor en Inmunología, Universidad de Barcelona, España.
Rodrigo Pacheco Rivera
Raquel Quatrini Nyqvist
Raquel Quatrini Nyqvist Doctora en Microbiología, Universidad de Chile, Chile.
Raquel Quatrini Nyqvist
Mario Rosembaltt Silber
Mario Rosembaltt Silber Doctor en Bioquímica, Wayne State University, Detroit, USA.
Mario Rosembaltt Silber
Cheril Tapia Rojas
Cheril Tapia Rojas Doctor en Ciencias Biológicas, mención Biología Celular y Molecular, Pontificia Universidad Católica de Chile.
Cheril Tapia Rojas
Nicole Tischler
Nicole Tischler Doctora en Biotecnología, Universidad Andrés Bello, Chile.
Nicole Tischler

Visiting Professors

Bernardo Pollak
Doctor en Plant Sciences, University of Cambridge, Inglaterra.
Esteban Engel
Doctor en Biotecnología, Universidad Andrés Bello, Chile.
Mauro Costa-Mattioli
Doctor en Biología Molecular, University of Nantes, Francia.
Sebastián Bernales
Doctor en Biología Celular, Universidad de California, Estados Unidos.
Francisco Herrera
Doctor en Bioquímica y Biología Molecular, Michigan State University, Estados Unidos.

Admission Process


Applicants must send their academic background through the digital platform of the Doctoral Program in Biotechnology and Bioentrepreneurship of Universidad San Sebastian. The documentation must certify the following requirements:

  • Academic degree of Bachelor, Master or Professional Degree in Biotechnology, Basic Sciences, Biomedical Sciences or in any area of knowledge with the ability to contribute to the development of research in the area of Biotechnology and Bioentrepreneurship. In case of having academic degrees of foreign origin, these must be equivalent to those mentioned, according to the International Classification of Education (ISCED-UNESCO), in force at the date of application.
  • Certification of grades of undergraduate and other studies, including those of advanced and postgraduate studies. The evaluation scales used and the minimum passing grade must be clearly specified.
  • Certificate of placement ranking of the graduates of the graduation cohort in their undergraduate and graduate studies. If the university does not issue this certificate, a letter from the institution will be required.
  • Curriculum vitae that accredits previous studies, presentations at congresses, research publications, among other activities.
  • Two letters of recommendation from academic professionals, sent confidentially via e-mail to the Doctoral Program address.
  • Statement of purpose that includes the formulation of a relevant topic of interest for study and research during the program, as well as the committed dedication. The applicant must specify his/her interests and research objectives in the short and long term, through a letter, whose length should not exceed 800 words.
  • Photocopy of both sides of identity card or passport, valid at the time of application.

The process for the selection of applicants consists of the evaluation of the applicant’s background, a personal interview and a knowledge test. In the case of applicants who reside outside the country or cannot travel to Santiago, the interview, examination and presentation will be conducted by videoconference.

Annual cost

Referential values 2023

  • Tuition: $351,600
  • Fee: $3.500.000


Ask about applying for a tuition scholarship, tuition fee and maintenance Benefit.